MINOA NIC GUM PACKAGE( 5 CAN )

Recently,Minoa Biotech announced a blockbustertechnoloay called Soft Salt, which can reduce theirritation of nicotine buccal products by more than70%
According to relevant research by Minoa, theburning sensation of nicotine buccal products doesnot come from nicotine itself, out from the interactionbetween the acetylcholine nerve and the TRP chan.nel during the human metabolic process of nicotine.The generation of the burning sensation results fromthe activation of the vanillic acid receptor of the TRHv1 channel. The functional group of capsaicin is the-CONH amide group. After being metabolized bycytochrome P450 cells, nicotine is oxidized to formcotinine, and a -CONH amide group functional groupis formed on the pyrrole ring of cotinine. In the caseof the activation of the cholinergic nerve, the amidearoup of cotinine determines the duration of the acti-vation of the TRP channel.
This discovery explains why arecoline, which isalso a cholinergic agonist and contains a pyridinering, does not cause a burning sensation in the oracavity when acting cirectly, and also explains whythne burning sensation of nicotine products astslonger than the metabolic half-life of nicotine
Through the application of the Soft Salt technolo-gy to compete for TRP receptors and block painSianals, it can sianificantly reduce the discomfort anoirritation caused bv nicotine products, and alsoreduce gastrointestinal irritation.